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FEBS Lett. 2002 Jul 31;524(1-3):31-6.

RIO1, an extraordinary novel protein kinase.

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  • 1Department Biologie I, Bereich Genetik, Ludwig-Maximilians-Universit√§t M√ľnchen, Maria-Ward-Strasse 1a, D-80638 Munich, Germany. M.Angermayr@lrz.uni-muenchen.de


RIO1 and Rio-related proteins display little similarity of primary sequence with conventional protein kinases. Based on secondary structure alignments, we show that it contains the domain structure (subdomains I-XI) and conserved secondary structure elements found in conventional protein kinases. We show that recombinant wild-type Rio1p isolated from Escherichia coli displays kinase activity which depends on autophosphorylation and magnesium or manganese as ATP-activating ions. An initial biochemical characterization of Rio1p is presented.

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