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Science. 2002 Jul 19;297(5580):353-6.

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

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  • 1Laboratories of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.

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  • Science 2002 Sep 27;297(5590):2209.

Abstract

It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid beta-peptide (Abeta) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Abeta in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta clearance.

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PMID:
12130773
[PubMed - indexed for MEDLINE]
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