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Pharmacotherapy. 2002 Jul;22(7):814-22.

Effects of orlistat on fat-soluble vitamins in obese adolescents.

Author information

  • 1Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1862, USA. Mcduffj@mail.nih.gov

Abstract

STUDY OBJECTIVES:

To determine whether orlistat causes fat-soluble vitamin deficiencies in African-American and Caucasian adolescents.

DESIGN:

Prospective, open-label pilot study.

SETTING:

Warren Grant Magnuson Clinical Center of the National Institutes of Health.

PATIENTS:

Seventeen adolescents with body mass indexes above the 95th percentile for age, race, and gender who also had at least one obesity-related comorbid condition.

INTERVENTION:

Subjects received orlistat 120 mg 3 times/day and a daily multivitamin supplement containing vitamin A 5000 IU, vitamin D 400 IU, vitamin E 300 IU, and vitamin K 25 microg.

MEASUREMENTS AND MAIN RESULTS:

During 3-6 months of orlistat treatment, acute absorption of retinol (vitamin A) was not significantly altered, but absorption of alpha-tocopherol (vitamin E) was significantly reduced compared with baseline levels (p<0.001). Serum levels of vitamins A and E did not change significantly; however, there was a nonsignificant decrease in vitamin K. Mean vitamin D levels were significantly reduced compared with baseline (p<0.02) after 1 month of orlistat, despite multivitamin supplementation.

CONCLUSION:

It may be prudent to monitor vitamin D concentrations in adolescents who take orlistat, even when a multivitamin is prescribed.

PMID:
12126214
[PubMed - indexed for MEDLINE]
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