J Neuropathol Exp Neurol. 2002 Jul;61(7):585-96.

Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases.

Camby I, Belot N, Lefranc F, Sadeghi N, de Launoit Y, Kaltner H, Musette S, Darro F, Danguy A, Salmon I, Gabius HJ, Kiss R.

Source

Laboratory Histopathology, Faculty of Medicine, Erasmus University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Abstract

We show that high-grade astrocytic tumors with high levels of galectin-1 expression are associated with dismal prognoses. The immunohistochemical analysis of galectin-1 expression of human U87 and U373 glioblastoma xenografts from the brains of nude mice revealed a higher level of galectin-1 expression in invasive areas rather than non-invasive areas of the xenografts. Nude mice intracranially grafted with U87 or U373 cells constitutively expressing low levels of galectin-1 (by stable transfection of an expression vector containing the antisense mRNA of galectin-1) had longer survival periods than those grafted with U87 or U373 cells expressing normal levels of galectin-1. Galectin-1 added to the culture media markedly and specifically increased cell motility levels in human neoplastic astrocytes. These effects are related to marked modifications in the organization of the actin cytoskeleton and the increase in small GTPase RhoA expression. All the data obtained indicate that galectin-1 enhances the migratory capabilities of tumor astrocytes and, therefore, their biological aggressiveness.

PMID:: 12125737; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Brain Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma. [Glia. 2001]
Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma.
Rorive S, Belot N, Decaestecker C, Lefranc F, Gordower L, Micik S, Maurage CA, Kaltner H, Ruchoux MM, Danguy A, et al. Glia. 2001 Mar 1; 33(3):241-55.
Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. [Brain Pathol. 2001]
Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration.
Camby I, Belot N, Rorive S, Lefranc F, Maurage CA, Lahm H, Kaltner H, Hadari Y, Ruchoux MM, Brotchi J, et al. Brain Pathol. 2001 Jan; 11(1):12-26.
Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern. [Biochem Biophys Res Commun. 2005]
Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern.
Camby I, Decaestecker C, Lefranc F, Kaltner H, Gabius HJ, Kiss R. Biochem Biophys Res Commun. 2005 Sep 16; 335(1):27-35.
Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines. [J Neurosurg. 2008]
Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines.
Jung TY, Jung S, Ryu HH, Jeong YI, Jin YH, Jin SG, Kim IY, Kang SS, Kim HS. J Neurosurg. 2008 Aug; 109(2):273-84.
The in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cells. [Neuropathol Appl Neurobiol. 2006]
The in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cells.
Servotte S, Camby I, Debeir O, Deroanne C, Lambert CA, Lapière CM, Kiss R, Nusgens B, Decaestecker C. Neuropathol Appl Neurobiol. 2006 Dec; 32(6):575-84.

See reviews... See all...

Cited by 14 PubMed Central articles

Galectins in hematological malignancies. [Am J Blood Res. 2011]
Galectins in hematological malignancies.
St-Pierre Y. Am J Blood Res. 2011; 1(2):119-29. Epub 2011 Sep 7.
Galectin-1-mediated biochemical controls of melanoma and glioma aggressive behavior. [World J Biol Chem. 2011]
Galectin-1-mediated biochemical controls of melanoma and glioma aggressive behavior.
Lefranc F, Mathieu V, Kiss R. World J Biol Chem. 2011 Sep 26; 2(9):193-201.
TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling. [Mol Cancer Res. 2010]
TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling.
Paulino VM, Yang Z, Kloss J, Ennis MJ, Armstrong BA, Loftus JC, Tran NL. Mol Cancer Res. 2010 Nov; 8(11):1558-67. Epub 2010 Sep 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Galectin-1 modulates human glioblastoma cell migration into the brain through mo...
Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases.
J Neuropathol Exp Neurol. 2002 Jul ;61(7):585-96.

PubMed
Study on cytokines IL-2, IL-6, IL-10 in patients of chronic allergic rhinitis tr...
Study on cytokines IL-2, IL-6, IL-10 in patients of chronic allergic rhinitis treated with acupuncture.
J Tradit Chin Med. 2002 Jun ;22(2):104-11.

PubMed
Evolutionary significance of cranial variation in Asian Homo erectus.
Evolutionary significance of cranial variation in Asian Homo erectus.
Am J Phys Anthropol. 2002 Aug ;118(4):301-23.

PubMed
Study of the role of leukotriene B()4 in abnormal function of human subchondral ...
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Arthritis Rheum. 2002 Jul ;46(7):1804-12.

PubMed
Biochemical outcome after radical prostatectomy or external beam radiation thera...
Biochemical outcome after radical prostatectomy or external beam radiation therapy for patients with clinically localized prostate carcinoma in the prostate specific antigen era.
Cancer. 2002 Jul 15 ;95(2):281-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: