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    Ann Pathol. 2002 Apr;22(2):96-101.

    [Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia].

    [Article in French]
    Korbi S, Trimeche M, Sriha B, Yacoubi MT, Hmissa S, Mokni M, Delvenne P, Boniver J, Rammeh S.

    Source

    Laboratoire d'Anatomie et de Cytologie Pathologiques, CHU Farhat Hached, 4000 Sousse, Tunisie, France. sadok.korbi@uc.mu.tn

    Abstract

    The purpose of this study was to evaluate the prevalence of Epstein-Barr virus in Hodgkin disease in Tunisia through a series of 77 cases. Association with Epstein-Barr virus was demonstrated by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization in 70% of cases and by latent membrane protein 1 (LMP1) immunohistochemistry in 58.4% of cases. EBER positive cases were more frequent in extreme age classes (<15 and>54 years) there was no correlation with sex, histologic sub-type and clinical stage. Our findings show a high prevalence for EBV infection in Tunisian Hodgkin's disease particularly among extreme ages.

    PMID:
    12124490
    [PubMed - indexed for MEDLINE]

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      • Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt. [J Hematop. 2010]
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        Audouin J, Diebold J, Nathwani B, Ishak E, Maclennan K, Mueller-Hermelink HK, Armitage JO, Weisenburger DD. J Hematop. 2010 Jun; 3(1):11-8. Epub 2010 May 28.

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