18O incorporation in the oxidation of N-methylcarbazole by lignin peroxidase and a model compound: a mechanistic insight into the oxidative N-demethylation of aromatic tertiary amines

Chem Commun (Camb). 2002 May 7:(9):946-7. doi: 10.1039/b201492k.

Abstract

Using 18O labelled reactants and/or solvent, the origin of the oxygen in the products of the oxidation of N-methylcarbazole by H2O2 catalysed by lignin peroxidase and a model compound has been determined, so getting important information about the mechanism of the oxidative N-demethylation of aromatic tertiary amines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Amines / metabolism*
  • Methylation
  • Oxidation-Reduction
  • Oxygen Isotopes / pharmacokinetics
  • Peroxidases / metabolism*

Substances

  • Amines
  • Oxygen Isotopes
  • Peroxidases
  • lignin peroxidase