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Prog Lipid Res. 2002 Sep;41(5):407-35.

Multi-subunit acetyl-CoA carboxylases.

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  • 1Department of Microbiology, B103 Chemical and Life Sciences Laboratory, University of Illinois, 601 S. Goodwin Avenue, Urbana, IL 61801, USA. j-cronan@life.uiuc.edu


Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.

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