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Infect Immun. 2002 Aug;70(8):4678-81.

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.

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  • 1Division of Infectious Diseases, Harvard Medical School, Boston, Massachusetts 02114, USA.

Abstract

We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.

PMID:
12117982
[PubMed - indexed for MEDLINE]
PMCID:
PMC128160
Free PMC Article

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