Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.)

Phytother Res. 2002 Jun;16(4):398-9. doi: 10.1002/ptr.979.

Abstract

Two antiaggregant compounds, thymol (compound 1) and 3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (compound 2) were isolated from the leaves of thyme (Thymus vulgaris L.). The structures were determined by (1)H-, (13)C-NMR and mass spectra (MS) studies. These compounds inhibited platelet aggregation induced by collagen, ADP, arachidonic acid (AA) and thrombin except that compound 2 did not inhibit platelet aggregation induced by thrombin.

MeSH terms

  • Humans
  • Molecular Structure
  • Nephelometry and Turbidimetry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / isolation & purification*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Thymus Plant / chemistry*

Substances

  • Plant Extracts
  • Platelet Aggregation Inhibitors