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Ann Neurol. 2002 Jun;51(6):783-6.

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease.

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  • 1Department of Pathology, Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.


Beta-secretase cleavage represents the first step in the generation of Abeta polypeptides and initiates the amyloid cascade that leads to neurodegeneration in Alzheimer's disease. By comparative Western blot analysis, we show a 2.7-fold increase in protein expression of the beta-secretase enzyme BACE in the brain cortex of Alzheimer's disease patients as compared to age-matched controls. Similarly, we found the levels of the amyloid precursor protein C-terminal fragment produced by beta-secretase to be increased by nearly twofold in Alzheimer's disease cortex.

[PubMed - indexed for MEDLINE]
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