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Curr Genet. 2002 Jun;41(3):123-31. Epub 2002 Jun 19.

Septins: a ring to part mother and daughter.

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  • 1Institute of Biochemistry, Swiss Federal Institute of Technology, Z├╝rich, Switzerland.

Abstract

The septins are well conserved GTPases found in animals and fungi. In yeast, they are required for the formation of 10-nm filaments, with which they co-localize at the bud neck. Therefore, septins have been proposed to be components of the neck filaments and to have polymerization properties. In support of this hypothesis, septin complexes purified from yeast and flies form filaments in vitro. However, recent studies have questioned the relevance of septin filament formation for septin function. Particularly, septin polymerization may not be required for their function in cytokinesis. New septin functions have also been recently uncovered: in budding yeast, the septin ring is required for the maintenance of cell polarity. It forms a cortical barrier that prevents lateral diffusion of membrane-associated proteins through the bud neck. Here, we review the most recent functional and biochemical data, to discuss whether there is a link between septin polymerization properties and septin function.

PMID:
12111093
[PubMed - indexed for MEDLINE]
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