Dev Cell. 2002 Jul;3(1):63-74.

Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling.

Source

Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln's Inn Field, London WC2A 3PX, United Kingdom.

Abstract

A molecular oscillator regulates the pace of vertebrate segmentation. Here, we show that the oscillator (clock) controls cyclic initiation of transcription in the unsegmented presomitic mesoderm (PSM). We identify an evolutionarily conserved 2.3 kb region in the murine Lunatic fringe (Lfng) promoter that drives periodic expression in the PSM. This region includes conserved blocks required for enhancing and repressing cyclic Lfng transcription, and to prevent continued expression in formed somites. We also show that dynamic expression in the cycling PSM is lost in the total absence of Notch signaling, and that Notch signaling acts directly via CBF1/RBP-Jkappa binding sites to regulate Lfng. These results are consistent with a model in which oscillatory Notch signaling underlies the segmentation clock and directly activates and indirectly represses Lfng expression.

PMID:: 12110168; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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GENBANK/AF492762

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Related citations

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Jiang YJ, Smithers L, Lewis J. Curr Biol. 1998 Dec 3; 8(24):R868-71.
Review Oscillator mechanism of Notch pathway in the segmentation clock. [Dev Dyn. 2007]
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Cited by 20 PubMed Central articles

The period of the somite segmentation clock is sensitive to Notch activity. [Mol Biol Cell. 2011]
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Kim W, Matsui T, Yamao M, Ishibashi M, Tamada K, Takumi T, Kohno K, Oba S, Ishii S, Sakumura Y, et al. Mol Biol Cell. 2011 Sep; 22(18):3541-9. Epub 2011 Jul 27.
Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. [PLoS One. 2009]
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