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The instructive role of dendritic cells on T-cell responses.
Institute for Research in Biomedicine, Bellinzona, Switzerland.
Immune responses are initiated in the T-cell areas of secondary lymphoid organs where naïve T lymphocytes encounter dendritic cells (DCs) that present antigens taken up in peripheral tissues. DCs represent the interface between the universe of foreign and tissue-specific antigens and T lymphocytes, and they are the key players in the regulation of cell-mediated immunity. We discuss how the nature of the DC maturation stimuli and the density and quality of DCs present in the T-cell areas of secondary lymphoid organs determine the magnitude and class of the T-cell response.
PMID: 12110131 [PubMed - indexed for MEDLINE]
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Cited by 7 PubMed Central articles
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The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo.
Lechmann M, Shuman N, Wakeham A, Mak TW.
Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11887-92. Epub 2008 Aug 13.
[Proc Natl Acad Sci U S A. 2008]
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Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course.
Freer G, Matteucci D, Mazzetti P, Tarabella F, Ricci E, Bozzacco L, Merico A, Pistello M, Ceccherini-Nelli L, Bendinelli M.
Retrovirology. 2008 Apr 17; 5:33. Epub 2008 Apr 17.
[Retrovirology. 2008]
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Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19.
Giordano D, Magaletti DM, Clark EA.
Blood. 2006 Feb 15; 107(4):1537-45. Epub 2005 Oct 25.
[Blood. 2006]
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