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Arthritis Res. 2002;4 Suppl 3:S127-32. Epub 2002 May 9.

The instructive role of dendritic cells on T-cell responses.

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  • 1Institute for Research in Biomedicine, Bellinzona, Switzerland.


Immune responses are initiated in the T-cell areas of secondary lymphoid organs where naïve T lymphocytes encounter dendritic cells (DCs) that present antigens taken up in peripheral tissues. DCs represent the interface between the universe of foreign and tissue-specific antigens and T lymphocytes, and they are the key players in the regulation of cell-mediated immunity. We discuss how the nature of the DC maturation stimuli and the density and quality of DCs present in the T-cell areas of secondary lymphoid organs determine the magnitude and class of the T-cell response.

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