Endothelial activation: intracellular signaling pa...[Arthritis Res. 2002]

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1: Arthritis Res. 2002;4 Suppl 3:S109-16. Epub 2002 May 9. Links

Endothelial activation: intracellular signaling pathways.

Pober JS.

Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06510, USA. jordan.pober@yale.edu

Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.

PMID: 12110129 [PubMed - indexed for MEDLINE]

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