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Mol Neurobiol. 2002 Jun;25(3):213-31.

Tau function and dysfunction in neurons: its role in neurodegenerative disorders.

Author information

  • 1Centro de Biología Molecular (CSIC-UAM), Universidad Autónoa, Madrid, Spain. javila@cbm.uam.es


Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.

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