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Mol Neurobiol. 2002 Jun;25(3):213-31.

Tau function and dysfunction in neurons: its role in neurodegenerative disorders.

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  • 1Centro de Biología Molecular (CSIC-UAM), Universidad Autónoa, Madrid, Spain.


Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.

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