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Curr Gene Ther. 2001 Sep;1(3):257-65.

The use of adenoviral vectors for genetic manipulation and analysis of primitive hematopoietic cells.

Author information

  • 1Division of Hematology/Oncology, University of Kentucky Medical Center, Lexington, KY 40536, USA. cjordan@pop.uky.edu

Abstract

Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.

PMID:
12109141
[PubMed - indexed for MEDLINE]
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