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J Control Release. 2002 Jul 18;82(1):127-35.

Controlled release of 4-nitroanisole from poly(lactic acid) nanoparticles.

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  • 1Group of Complex Fluids Physics, Department of Applied Physics, University of Almería, 04120 Almería, Spain. msromero@ual.es


The controlled release of 4-nitroanisole from polylactide nanoparticles with different morphologies is reported. Two theoretical equations have been used in an attempt to fit the experimental results. Good agreement between theory and experiment was found for short release time. The estimated values of the diffusion coefficient of 4-nitroanisole in these nanoparticles, at short times (up to 50% release), were all approximately 10(-19) m(2)s(-1). At long time some differences in release behaviour were observed for different morphologies.

Copyright 2002 Elsevier Science B.V.

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