Your browser version may not work well with NCBI's Web applications. More information here...
1: Neurology. 2002 Jul 9;59(1):123-5.Click here to read Links
Comment in:
Neurology. 2003 Sep 9;61(5):721; author reply 721.

Donepezil and flight simulator performance: effects on retention of complex skills.

Yesavage JA, Mumenthaler MS, Taylor JL, Friedman L, O'Hara R, Sheikh J, Tinklenberg J, Whitehouse PJ.

Palo Alto Veterans Affairs Health Care System, Stanford University School of Medicine, Stanford, CA 94305-5550, USA. yesavage@stanford.edu

We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability to retain the capacity to perform a set of complex simulator tasks than the placebo group, p < 0.05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults.

PMID: 12105320 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Donepezil (Aricept® , Aricept® ODT)

    Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) associated with Alzheime...

  • Donepezil (Aricept, Razadyne, Razadyne, ...)

    How do Alzheimer's drugs compare for treating symptoms?

  • Source: AHFS Consumer Medication Information