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1: Lancet. 2002 Jun 29;359(9325):2249-51.Click here to read Links

A disseminated multidrug-resistant clonal group of uropathogenic Escherichia coli in pyelonephritis.

Johnson JR, Manges AR, O'Bryan TT, Riley LW.

Medical Service, Minneapolis VA Medical Center and Department of Medicine, University of Minnesota, Minneapolis, MN, USA. johns007@tc.umn.edu

In acute pyelonephritis, bacterial resistance to co-trimoxazole predicts treatment failure, but the clonal basis of such resistance is undefined. We did molecular and serological analyses of 170 Escherichia coli urine isolates obtained in 1994-96 from women with acute pyelonephritis. 12 (7%) of the pyelonephritis isolates were in clonal group A (CGA; responsible for 38-51% of co-trimoxazole resistance in acute cystitis), including ten (34%) of 29 isolates that were resistant to co-trimoxazole. CGA isolates were obtained from diverse locations across the USA and were related to the O15:K52:H1 clone of the 1986-87 outbreak in London, UK. Thus, CGA is broadly disseminated and contributes to co-trimoxazole resistance in pyelonephritis as well as in cystitis.

PMID: 12103291 [PubMed - indexed for MEDLINE]

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