Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
EMBO Rep. 2002 Jul;3(7):628-35.

A complex prediction: three-dimensional model of the yeast exosome.

Author information

  • 1EMBL, Meyerhofstrasse, Heidelberg, Germany.

Abstract

We present a model of the yeast exosome based on the bacterial degradosome component polynucleotide phosphorylase (PNPase). Electron microscopy shows the exosome to resemble PNPase but with key differences likely related to the position of RNA binding domains, and to the location of domains unique to the exosome. We use various techniques to reduce the many possible models of exosome subunits based on PNPase to just one. The model suggests numerous experiments to probe exosome function, particularly with respect to subunits making direct atomic contacts and conserved, possibly functional residues within the predicted central pore of the complex.

PMID:
12101094
[PubMed - indexed for MEDLINE]
PMCID:
PMC1084189
Free PMC Article

Images from this publication.See all images (5)Free text

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk