Synthesis of (E)-4-hydroxydimethylallyl diphosphat...[J Org Chem. 2002]

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1: J Org Chem. 2002 Jul 12;67(14):5009-10. Links

Synthesis of (E)-4-hydroxydimethylallyl diphosphate. An intermediate in the methyl erythritol phosphate branch of the isoprenoid pathway.

Fox DT, Poulter CD.

Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.

The syntheses of (E)-1-hydroxy-2-methyl-2-buten-4-yl diphosphate ((E)-4-hydroxydimethylallyl diphosphate, HDMAPP), an intermediate in the methyl erythritol phosphate pathway, and (E)-[4-(2)H]HDMAPP were accomplished in two steps from (E)-4-chloro-2-methyl-2-butenal. The synthetic route is easily adaptable for the facile incorporation of tritium at C-4 of the diphosphate.

PMID: 12098326 [PubMed]

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[Curr Pharm Des. 2007]
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