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Nature. 2002 Jul 4;418(6893):38-9.

RNA interference in adult mice.

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  • 1Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305-5208, USA.


RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.

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