Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Cell Proteomics. 2002 Apr;1(4):323-33.

Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae.

Author information

  • 1Institute for Systems Biology, Seattle, Washington 98103, USA.

Abstract

Using an integrated genomic and proteomic approach, we have investigated the effects of carbon source perturbation on steady-state gene expression in the yeast Saccharomyces cerevisiae growing on either galactose or ethanol. For many genes, significant differences between the abundance ratio of the messenger RNA transcript and the corresponding protein product were observed. Insights into the perturbative effects on genes involved in respiration, energy generation, and protein synthesis were obtained that would not have been apparent from measurements made at either the messenger RNA or protein level alone, illustrating the power of integrating different types of data obtained from the same sample for the comprehensive characterization of biological systems and processes.

PMID:
12096114
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk