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FEBS Lett. 2002 Jul 3;522(1-3):156-60.

Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation.

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  • 1Molecular Tissue Repair Unit, Department of Surgery, Royal Free and University College Medical School, University College London, Rowland Hill Street, UK.

Erratum in

  • FEBS Lett. 2006 May 1;580(10):2530.

Abstract

The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.

PMID:
12095637
[PubMed - indexed for MEDLINE]
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