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Software and methods for oligonucleotide and cDNA array data analysis.
The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. dlockhart@ambitbio.com
Two HTML-based programs were developed to analyze and filter gene-expression data: 'Bullfrog' for Affymetrix oligonucleotide arrays and 'Spot' for custom cDNA arrays. The programs provide intuitive data-filtering tools through an easy-to-use interface. A background subtraction and normalization program for cDNA arrays was also built that provides an informative summary report with data-quality assessments. These programs are freeware to aid in the analysis of gene-expression results and facilitate the search for genes responsible for interesting biological processes and phenotypes.
PMID: 12093384 [PubMed - indexed for MEDLINE]
PMCID: PMC139376
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Cited by 2 PubMed Central articles
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Adult mouse brain gene expression patterns bear an embryologic imprint.
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[Proc Natl Acad Sci U S A. 2005]
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Local regulation of fat metabolism in peripheral nerves.
Verheijen MH, Chrast R, Burrola P, Lemke G.
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[Genes Dev. 2003]