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Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9562-7. Epub 2002 Jun 27.

Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.

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  • 1Department of Genetics, Washington University Medical School, St. Louis, MO, 63110, USA.

Abstract

We measured daily gene expression in heads of control and period mutant Drosophila by using oligonucleotide microarrays. In control flies, 72 genes showed diurnal rhythms in light-dark cycles; 22 of these also oscillated in free-running conditions. The period gene significantly influenced the expression levels of over 600 nonoscillating transcripts. Expression levels of several hundred genes also differed significantly between control flies kept in light-dark versus constant darkness but differed minimally between per(01) flies kept in the same two conditions. Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent.

PMID:
12089325
[PubMed - indexed for MEDLINE]
PMCID:
PMC123180
Free PMC Article
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