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Cancer Cell. 2002 Apr;1(3):213-5.

RUNX: a trilogy of cancer genes.

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  • 1Division of Molecular Genetics, The Netherlands Cancer Institute, Antoni van Leeuwenhoek ziekenhuis, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands


The RUNX family of transcription factors plays pivotal roles during normal development and in neoplasias. Recent data involve RUNX3 as an important tumor suppressor in gastric cancers and pose interesting questions about how perturbed levels and interspecific competition among RUNX family members may contribute to tumorigenesis.

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