Polymer-assisted Horner-Emmons olefination using PASSflow reactors: pure products without purification

Wladimir Solodenko; Ulrich Kunz; Gerhard Jas; Andreas Kirschning

doi:10.1016/s0960-894x(02)00265-2

Polymer-assisted Horner-Emmons olefination using PASSflow reactors: pure products without purification

Bioorg Med Chem Lett. 2002 Jul 22;12(14):1833-5. doi: 10.1016/s0960-894x(02)00265-2.

Authors

Wladimir Solodenko¹, Ulrich Kunz, Gerhard Jas, Andreas Kirschning

Affiliation

¹ Institut für Organische Chemie der Universität Hannover, Schneiderberg 1B, Germany.

PMID: 12086828
DOI: 10.1016/s0960-894x(02)00265-2

Abstract

A PASSflow protocol for the Horner-Emmons olefination of aldehydes using polymer-bound hydroxide ions in flowthrough reactors is presented which allows preparation of alkenes in very high yield with minimal purification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry
Alkenes / chemistry*
Chemistry, Organic / instrumentation
Chemistry, Organic / methods*
Combinatorial Chemistry Techniques
Glass / chemistry
Hydroxides / chemistry
Magnetic Resonance Spectroscopy
Microscopy, Electron, Scanning
Organophosphonates / chemistry
Polystyrenes / chemistry*
Stereoisomerism

Substances

Aldehydes
Alkenes
Hydroxides
Organophosphonates
Polystyrenes
hydroxide ion