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1: Trends Neurosci. 2002 Jun;25(6):284-6.Click here to read Links
Erratum in:
Trends Neurosci 2002 Jul;25(7):378.

Jekyll-Hyde neurotrophins: the story of proNGF.

Ibáñez CF.

Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden. carlos.ibanez@neuro.ki.se [corrected]

Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide is both a preferential high-affinity ligand for p75(NTR) (with minimal affinity for trkA) and a potent inducer of p75(NTR)-mediated neuronal cell death are likely to change our understanding of neurotrophin physiology and our ability to manipulate their signaling pathways.

PMID: 12086739 [PubMed - indexed for MEDLINE]