Generation of dendritic cell-based vaccines for cancer therapy

Br J Cancer. 2002 May 20;86(10):1529-33. doi: 10.1038/sj.bjc.6600316.

Abstract

Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we discuss various conditions, which are important during generation and administration of dendritic cells to elicit a tumouricidal T cell-based immune response.

Publication types

  • Review

MeSH terms

  • Antigen Presentation
  • Antigens, Neoplasm / immunology
  • Cancer Vaccines / administration & dosage
  • Cancer Vaccines / adverse effects
  • Cancer Vaccines / immunology
  • Cancer Vaccines / therapeutic use*
  • Cell Differentiation / drug effects
  • Cells, Cultured / drug effects
  • Cells, Cultured / transplantation
  • Clinical Trials as Topic
  • Cytokines / genetics
  • Cytokines / pharmacology
  • Dendritic Cells / immunology*
  • Dendritic Cells / transplantation
  • Fever / etiology
  • Hematopoietic Stem Cell Mobilization
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Immunization
  • Immunotherapy, Active* / adverse effects
  • Leukapheresis
  • Lymphatic Diseases / etiology
  • Lymphocyte Activation
  • Monocytes / cytology
  • Monocytes / drug effects
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Peptide Fragments / immunology
  • T-Lymphocytes, Cytotoxic / immunology
  • Transfection

Substances

  • Antigens, Neoplasm
  • Cancer Vaccines
  • Cytokines
  • Peptide Fragments