Abstract
Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we discuss various conditions, which are important during generation and administration of dendritic cells to elicit a tumouricidal T cell-based immune response.
Copyright 2002 Cancer Research UK
MeSH terms
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Antigen Presentation
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Antigens, Neoplasm / immunology
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Cancer Vaccines / administration & dosage
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Cancer Vaccines / adverse effects
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Cancer Vaccines / immunology
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Cancer Vaccines / therapeutic use*
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Cell Differentiation / drug effects
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Cells, Cultured / drug effects
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Cells, Cultured / transplantation
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Clinical Trials as Topic
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Cytokines / genetics
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Cytokines / pharmacology
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Dendritic Cells / immunology*
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Dendritic Cells / transplantation
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Fever / etiology
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Hematopoietic Stem Cell Mobilization
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / drug effects
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Hematopoietic Stem Cells / immunology
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Humans
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Immunization
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Immunotherapy, Active* / adverse effects
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Leukapheresis
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Lymphatic Diseases / etiology
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Lymphocyte Activation
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Monocytes / cytology
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Monocytes / drug effects
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Neoplasms / immunology
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Neoplasms / therapy*
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Peptide Fragments / immunology
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T-Lymphocytes, Cytotoxic / immunology
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Transfection
Substances
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Antigens, Neoplasm
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Cancer Vaccines
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Cytokines
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Peptide Fragments