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Am J Public Health. 2002 Jul;92(7):1173-7.

Use of topical sunscreens and the risk of malignant melanoma: a meta-analysis of 9067 patients from 11 case-control studies.

Author information

  • 1Division of Radiation Oncology, Department of Clinical Oncology, Marshfield Clinic Cancer Center, Marshfield, WI, USA. metaresearch@hotmail.com

Abstract

OBJECTIVES:

This study examined the methodology of epidemiological studies that suggest use of topical sunscreen preparations is associated with increased risk of malignant melanoma.

METHODS:

We pooled data from observational studies using a general variance-based meta-analytic method that employed confidence intervals (previously described). The outcome of interest was a summary relative risk (RR) reflecting the risk of melanoma associated with sunscreen use versus nonuse. Sensitivity analyses were performed when necessary to explain any observed statistical heterogeneity.

RESULTS:

Combining studies that used non-heterogeneous data yielded a summary RR of 1.01, indicating no association between sunscreen use and development of malignant melanoma.

CONCLUSIONS:

The available epidemiological data do not support the existence of a relationship between topical sunscreen use and an increased risk of cutaneous malignant melanoma.

PMID:
12084704
[PubMed - indexed for MEDLINE]
PMCID:
PMC1447210
Free PMC Article
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