J Bacteriol. 2002 Jul;184(14):4025-32.

Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes.

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Program in Microbiology and Molecular Genetics, Emory University, Atlanta, Georgia 30322, USA.

Abstract

We used microarrays and real-time reverse transcription-PCR to analyze the global transcriptional response of Mycobacterium tuberculosis to low pH in vitro, which may mimic an environmental signal encountered by phagocytosed mycobacteria. Eighty-one genes were differentially expressed >1.5-fold, including many involved in fatty acid metabolism. The most highly induced genes showed homology with nonribosomal peptide synthetases/polyketide synthases.

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PMCID:: PMC135184

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