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Science. 2002 Jun 21;296(5576):2176-8.

Unique chromatin remodeling and transcriptional regulation in spermatogenesis.

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  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, B. P. 10142, 67404 Illkirch, Strasbourg, France. paolosc@igbmc.u-strasbg.fr


Most of our knowledge of transcriptional regulation comes from studies in somatic cells. However, increasing evidence reveals that gene regulation mechanisms are different in haploid germ cells. A number of highly specialized strategies operate during spermatogenesis. These include a unique chromatin reorganization program and the use of distinct promoter elements and specific transcription factors. Deciphering the rules governing transcriptional control during spermatogenesis will provide valuable insights of biomedical importance.

[PubMed - indexed for MEDLINE]
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