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    Nature. 1975 Dec 18;258(5536):577-80.

    Identification of two related pentapeptides from the brain with potent opiate agonist activity.

    Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR.

    Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.

    PMID: 1207728 [PubMed - indexed for MEDLINE]

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