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Identification of two related pentapeptides from the brain with potent opiate agonist activity.
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
PMID: 1207728 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Evolutionary sequence modeling for discovery of peptide hormones.
Sonmez K, Zaveri NT, Kerman IA, Burke S, Neal CR, Xie X, Watson SJ, Toll L.
PLoS Comput Biol. 2009 Jan; 5(1):e1000258. Epub 2009 Jan 9.
[PLoS Comput Biol. 2009]
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Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins.
Terskiy A, Wannemacher KM, Yadav PN, Tsai M, Tian B, Howells RD.
Life Sci. 2007 Nov 30; 81(23-24):1593-601. Epub 2007 Oct 5.
[Life Sci. 2007]
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Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
Shiotani K, Li T, Miyazaki A, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Lazarus LH, Okada Y.
Bioorg Med Chem Lett. 2007 Nov 1; 17(21):5768-71. Epub 2007 Aug 28.
[Bioorg Med Chem Lett. 2007]
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