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Dev Biol. 2002 Jul 1;247(1):127-36.

Downstream targets of let-60 Ras in Caenorhabditis elegans.

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  • 1Department of Developmental Biology and Genetics, Stanford University Medical School, California 94305, USA.


In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras.

(c) 2002 Elsevier Science (USA).

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