Blood. 2002 Jul 1;100(1):347-9.

Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis.

Panzer-Grümayer ER, Fasching K, Panzer S, Hettinger K, Schmitt K, Stöckler-Ipsiroglu S, Haas OA.

Source

Children's Cancer Research Institute, St Anna Kinderspital, University of Vienna, Austria. panzer@ccri.univie.ac.at

Abstract

A hyperdiploid karyotype is found in 30% of B-cell precursor acute lymphoblastic leukemias in childhood. The time of nondisjunction of chromosomes leading to hyperdiploidy during leukemogenesis is unknown. We used the 3 clonotypic immunoglobulin heavy chain (IgH) gene rearrangements as molecular markers for each of the 3 chromosomes 14 in a case with hyperdiploid acute lymphoblastic leukemia to define the order of events-namely, somatic recombination and nondisjunction of chromosomes-during leukemia development. A partial sequence homology of the incomplete DJ(H) rearrangement with 1 of the 2 nonfunctional VDJ(H) rearrangements suggests that the doubling of chromosomes had occurred after this DJ(H) rearrangement and thus during early B-cell differentiation. The occurrence of the nondisjunction of chromosomes as well as ongoing rearrangement processes in utero were confirmed by the presence of all 3 IgH rearrangements in neonatal blood spots, providing the first evidence that hyperdiploidy formation is an early event in leukemogenesis in these leukemias.

PMID:: 12070048; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Immunoglobulin Heavy Chains

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia. [Eur J Haematol. 1999]
Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia.
Rosenquist R, Thunberg U, Li AH, Forestier E, Lönnerholm G, Lindh J, Sundström C, Sällström J, Holmberg D, Roos G. Eur J Haematol. 1999 Sep; 63(3):171-9.
Molecular analysis of single colonies reveals a diverse origin of initial clonal proliferation in B-precursor acute lymphoblastic leukemia that can precede the t(12;21) translocation. [Cancer Res. 2001]
Molecular analysis of single colonies reveals a diverse origin of initial clonal proliferation in B-precursor acute lymphoblastic leukemia that can precede the t(12;21) translocation.
Weston VJ, McConville CM, Mann JR, Darbyshire PJ, Lawson S, Gordon J, Moss PA, Taylor AM, Stankovic T. Cancer Res. 2001 Dec 1; 61(23):8547-53.
TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. [Leuk Res. 2003]
TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia.
Pine SR, Wiemels JL, Jayabose S, Sandoval C. Leuk Res. 2003 Feb; 27(2):155-64.
Review Unusual immunoglobulin and T-cell receptor gene rearrangement patterns in acute lymphoblastic leukemias. [Curr Top Microbiol Immunol. 1999]
Review Unusual immunoglobulin and T-cell receptor gene rearrangement patterns in acute lymphoblastic leukemias.
Szczepański T, Pongers-Willemse MJ, Langerak AW, van Dongen JJ. Curr Top Microbiol Immunol. 1999; 246:205-13; discussion 214-5.
Review High hyperdiploid childhood acute lymphoblastic leukemia. [Genes Chromosomes Cancer. 2009]
Review High hyperdiploid childhood acute lymphoblastic leukemia.
Paulsson K, Johansson B. Genes Chromosomes Cancer. 2009 Aug; 48(8):637-60.

See reviews... See all...

Cited by 4 PubMed Central articles

Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. [Proc Natl Acad Sci U S A. 2010]
Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.
Paulsson K, Forestier E, Lilljebjörn H, Heldrup J, Behrendtz M, Young BD, Johansson B. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21719-24. Epub 2010 Nov 22.
Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia. [Blood Cells Mol Dis. 2010]
Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia.
Wiemels JL, Kang M, Chang JS, Zheng L, Kouyoumji C, Zhang L, Smith MT, Scelo G, Metayer C, Buffler P, et al. Blood Cells Mol Dis. 2010 Oct 15; 45(3):186-91. Epub 2010 Aug 5.
Computer aided analysis of additional chromosome aberrations in Philadelphia chromosome positive acute lymphoblastic leukaemia using a simplified computer readable cytogenetic notation. [BMC Bioinformatics. 2003]
Computer aided analysis of additional chromosome aberrations in Philadelphia chromosome positive acute lymphoblastic leukaemia using a simplified computer readable cytogenetic notation.
Bradtke J, Balz H, Fonatsch C, Heinze B, Jauch A, Mohr B, Schoch C, Rieder H. BMC Bioinformatics. 2003 Jan 28; 4:4. Epub 2003 Jan 28.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor...
Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis.
Blood. 2002 Jul 1 ;100(1):347-9.

PubMed
Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxy...
Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry.
Blood. 2002 Jul 1 ;100(1):178-83.

PubMed
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate:...
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
Biochim Biophys Acta. 2002 May 23 ;1582(1-3):132-7.

PubMed
Changes in antibiotic prescribing for children after a community-wide campaign.
Changes in antibiotic prescribing for children after a community-wide campaign.
JAMA. 2002 Jun 19 ;287(23):3103-9.

PubMed
Truth survival in clinical research: an evidence-based requiem?
Truth survival in clinical research: an evidence-based requiem?
Ann Intern Med. 2002 Jun 18 ;136(12):888-95.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: