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    Antimicrob Agents Chemother. 2002 Jul;46(7):2303-6.

    blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513.

    Arduino SM, Roy PH, Jacoby GA, Orman BE, Pineiro SA, Centron D.

    Source

    Facultad de Medicina de la Universidad de Buenos Aires, Paraguay 2155 (1121)Capital Federal, Argentina. sarduino@aol.com

    Abstract

    Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that bla(CTX-M-2) was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.

    PMID:
    12069995
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC127297
    Free PMC Article

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