Low, but not high, doses of melatonin entrained a ...[Chronobiol Int. 2002]

Search for

Advanced Search (beta)

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Chronobiol Int. 2002 May;19(3):649-58.Links

Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period.

Lewy AJ, Emens JS, Sack RL, Hasler BP, Bernert RA.

Department of Psychiatry, Oregon Health & Science University, Portland, USA.

In a previous report, we were unable to entrain one out of seven totally blind people with free-running endogenous melatonin rhythms to 10 mg of exogenous melatonin. This person had the longest circadian period (24.9 h) of the group. We now find that this person can be entrained to 0.5 mg of melatonin, but not to 20 mg. These results are consistent with the idea that too much melatonin may spill over onto the wrong zone of the melatonin phase-response curve.

PMID: 12069043 [PubMed - indexed for MEDLINE]

Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin. [Brain Res. 2001]
Entrainment of free-running circadian rhythms by melatonin in blind people. [N Engl J Med. 2000]
The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjects. [J Biol Rhythms. 2003]
Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin. [Neurosci Lett. 2001]
Melatonin entrains free-running blind people according to a physiological dose-response curve. [Chronobiol Int. 2005]
» See all Related Articles...

Display Show

Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period.

Related Articles