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Jpn J Ophthalmol. 2002 May-Jun;46(3):261-9.

Effects of aging on the first and second-order kernels of multifocal electroretinogram.

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  • 1Department of Ophthalmology, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.



To determine the effects of aging on the first and second-order kernels of the multifocal electroretinogram (ERG).


Multifocal ERGs were recorded from 52 healthy subjects (52 eyes) (0 >or= refractive error >or= -3.0 diopter). The ages of the subjects ranged from 12-76 years with a mean (+/-SD) of 44.0 +/- 20.2 years. The Visual Evoked Response Imaging System was used. The effects of aging on the response densities and on the implicit times of the first positive wave (P1) of the first-order kernel, and of the second and third positive waves (P2 and P3) of the second-order kernel were analyzed for the different age groups.


The response densities of the first-order kernel P1 and second-order kernel P2 waves decreased significantly, and the implicit times of the second-order kernel P2, and P3 were significantly prolonged (P <.05) in subjects over 50 years of age.


The results suggest that the age of the subject should be considered when evaluating retinal function using multifocal ERGs in basic and clinical studies.

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