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    FEBS Lett. 2002 Apr 24;517(1-3):277-80.

    Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.

    Source

    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

    Abstract

    Latent transforming growth factor-beta (TGF-beta) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-beta. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell types, but secretion occurs after coexpression with TGF-beta. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-beta propeptide.

    PMID:
    12062452
    [PubMed - indexed for MEDLINE]

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