Novel cDNAs encoding salivary proteins from the malaria vector Anopheles gambiae

FEBS Lett. 2002 Apr 24;517(1-3):67-71. doi: 10.1016/s0014-5793(02)02578-4.

Abstract

Several genes encoding salivary components of the mosquito Anopheles gambiae were identified using a selective trapping approach. Among these, five corresponded to genes expressed specifically in female glands and their role may possibly be linked to blood-feeding. Our collection included a fourth member of the D7 protein family and two polypeptides that showed weak similarity to anti-coagulants from distantly related species. Moreover, we identified two additional members of a novel group of proteins that we named glandins. The isolation of tissue-specific genes represents a first step toward a deeper molecular analysis of mosquito salivary secretions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anopheles / genetics*
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • DNA, Complementary / isolation & purification
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental*
  • Insect Proteins / biosynthesis
  • Insect Proteins / genetics*
  • Insect Vectors / genetics*
  • Malaria
  • Male
  • Molecular Sequence Data
  • Salivary Glands / metabolism*
  • Salivary Proteins and Peptides / biosynthesis
  • Salivary Proteins and Peptides / genetics*
  • Sequence Homology, Amino Acid

Substances

  • DNA, Complementary
  • Insect Proteins
  • Salivary Proteins and Peptides