Clin Chem Lab Med. 2002 Apr;40(4):325-32.

Fecal elastase-1 as a test for pancreatic function: a review.

Source

Istituto di Scienze Biomediche, Ospedale Luigi Sacco, Milano, Italy.

Abstract

Pancreatic elastase-1 is a specific human protease synthetized by the acinar cells. Immunoreactive elastase-1 cannot be detected in either porcine or bovine pancreatic enzyme preparations. It is very stable and, in contrast to fecal chymotrypsin, elastase is unaffected by exogenous pancreatic enzyme treatment, and correlates well with exocrine pancreatic function tests. The measurement of this proteolytic enzyme in stool by means of an enzyme-linked immunosorbent assay (ELISA) is a sensitive, specific, and relatively inexpensive non-invasive test. It is an accurate function test for patients with chronic pancreatitis confirmed by endoscopic retrograde cholangiopancreatography and computerized axial tomography. It shows higher sensitivity and specificity for exocrine pancreatic insufficiency than fecal chymotrypsin determination and is comparable to oral pancreatic function tests such as the pancreolauryl test.

Comment in

Clin Chem Lab Med. 2005;43(1):97-8.

PMID:: 12059069; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Pancreatic Elastase

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Cited by 1 PubMed Central article

Pancreatic function, quality of life and costs at long-term follow-up after acute pancreatitis. [World J Gastroenterol. 2010]
Pancreatic function, quality of life and costs at long-term follow-up after acute pancreatitis.
Andersson B, Pendse ML, Andersson R. World J Gastroenterol. 2010 Oct 21; 16(39):4944-51.

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