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Science. 2002 Jun 7;296(5574):1821-5.

A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains.

Author information

  • 1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA. richard.anderson@utsouthwestern.edu

Abstract

The surface membrane of cells is studded with morphologically distinct regions, or domains, like microvilli, cell-cell junctions, and coated pits. Each of these domains is specialized for a particular function, such as nutrient absorption, cell-cell communication, and endocytosis. Lipid domains, which include caveolae and rafts, are one of the least understood membrane domains. These domains are high in cholesterol and sphingolipids, have a light buoyant density, and function in both endocytosis and cell signaling. A major mystery, however, is how resident molecules are targeted to lipid domains. Here, we propose that the molecular address for proteins targeted to lipid domains is a lipid shell.

PMID:
12052946
[PubMed - indexed for MEDLINE]
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