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Hypertension. 2002 Jun;39(6):1044-9.

Linkage of essential hypertension to chromosome 18q.

Author information

  • 1deCODE genetics, Inc, Reykjavik, Iceland. kris@ decode.is

Abstract

We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.

PMID:
12052839
[PubMed - indexed for MEDLINE]
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