Abstract
Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).
MeSH terms
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Administration, Oral
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Animals
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Biological Availability
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Clodronic Acid / analogs & derivatives
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Diphosphonates / chemical synthesis
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Diphosphonates / chemistry*
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Diphosphonates / pharmacokinetics*
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Drug Delivery Systems
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Etidronic Acid / analogs & derivatives
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Humans
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Hydrogen-Ion Concentration
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Hydrolysis
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Intestinal Absorption
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Prodrugs / chemical synthesis
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Prodrugs / chemistry*
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Prodrugs / pharmacokinetics*
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Structure-Activity Relationship
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Tissue Distribution
Substances
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Diphosphonates
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Prodrugs
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Clodronic Acid
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Etidronic Acid