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Mech Dev. 2002 Jul;115(1-2):123-6.

Cardiac specific expression of Xenopus Popeye-1.

Author information

  • 1Abt. Entwicklungsbiochemie, Junior Group SFB 271, Universität Göttingen, Humboldtallee 23, 37073 Göttingen, Germany.

Abstract

Popeye genes code for putative transmembrane proteins that are predominantly expressed in heart and skeletal muscle. Here we report on the isolation and expression of a previously unknown Xenopus member of this family, Xenopus Popeye-1 (Xpop-1). Xpop-1 is 60-65% identical to other vertebrate Pop-1 genes at the protein level. Whole-mount in situ hybridization studies revealed a highly specific expression of Xpop-1 whose transcripts are restricted to the embryonic heart and become enriched in the forming ventricle. Interestingly, unlike other known vertebrate Popeye genes, Xpop-1 is exclusively expressed in cardiac tissue and absent from skeletal muscle.

PMID:
12049775
[PubMed - indexed for MEDLINE]

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