DNA binding and bending to initiate packaging of phage lambda DNA

Mol Cell. 2002 May;9(5):928-9. doi: 10.1016/s1097-2765(02)00536-1.

Abstract

Physical and genetic studies verify that the DNA binding domain of protein gpNu1 (which initiates packaging of phage lambda DNA) is a winged helix-turn-helix (w HTH) and that gpNu1 dimers bind sites that are brought close through DNA bending.

Publication types

  • Comment

MeSH terms

  • Bacteriophage lambda / genetics*
  • DNA, Viral / metabolism*
  • Helix-Turn-Helix Motifs
  • Nucleic Acid Conformation*
  • Viral Proteins / genetics
  • Viral Proteins / metabolism

Substances

  • DNA, Viral
  • Viral Proteins
  • lambda phage protein Nu 1