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Mol Cell. 2002 May;9(5):923-5.

The SCF ubiquitin ligase: an extended look.

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  • 1Stanford University School of Medicine, Department of Pathology, 300 Pasteur Drive, Palo Alto, CA 94305, USA.


The SCF E3 ubiquitin ligases select specific proteins for ubiquitination (and typically destruction) by coupling variable adaptor (F box) proteins that bind protein substrates to a conserved catalytic engine containing a cullin, Cul1, and the Rbx1/Roc1 RING finger protein. A new crystal structure of the SCF(Skp2) ubiquitin ligase shows the molecular organization of this complex and raises important questions as to how substrate ubiquitination is accomplished.

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