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Microbes Infect. 2002 May;4(6):635-46.

Tuberculosis unleashed: the impact of human immunodeficiency virus infection on the host granulomatous response to Mycobacterium tuberculosis.

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  • 1Tuberculosis/Mycobacteriology Branch, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road NE, Atlanta, GA 30333, USA.


The granuloma plays a critical role in the host immune response to Mycobacterium tuberculosis, containing the organism and confining it in a latent state in most infected individuals. Indeed, approximately one-third of the world's population has latent M. tuberculosis infection. However, over the past decade, the human immunodeficiency virus type 1 (HIV-1) pandemic has profoundly affected the incidence and clinicopathological features of tuberculosis. This review examines the immunological mechanisms whereby HIV-1 impairs the establishment, maintenance and function of the tuberculous granuloma.

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